about
Evaluation of [18F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer.DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry.ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress.TP53-dependent autophagy links the ATR-CHEK1 axis activation to proinflammatory VEGFA production in human bronchial epithelial cells exposed to fine particulate matter (PM2.5).Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer.ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers.Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cellsResistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition.The essential kinase ATR: ensuring faithful duplication of a challenging genome.Molecular genetics of osteosarcoma.Reevaluation of ATR signaling in primary resting chronic lymphocytic leukemia cells: evidence for pro-survival or pro-apoptotic function.Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.Cryo-EM structure of human ATR-ATRIP complex.ATR Is a Therapeutic Target in Synovial Sarcoma.Directing the use of DDR kinase inhibitors in cancer treatment.Targeting ataxia telangiectasia-mutated- and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized therapy.Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes.Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells.Combined Inhibition of ATR and WEE1 as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer.Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis.ZEB1 inhibition sensitizes cells to the ATR inhibitor VE-821 by abrogating epithelial-mesenchymal transition and enhancing DNA damage.Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models.ATR kinase inhibitors NVP-BEZ235 and AZD6738 effectively penetrate the brain after systemic administration.DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damageInactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 InhibitorsThe Impact of p53 Dysfunction in ATR Inhibitor Cytotoxicity and Chemo- and Radiosensitisation
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P2860
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Molecular Pathways: Targeting ATR in Cancer Therapy
@en
type
label
Molecular Pathways: Targeting ATR in Cancer Therapy
@en
prefLabel
Molecular Pathways: Targeting ATR in Cancer Therapy
@en
P2860
P1476
Molecular Pathways: Targeting ATR in Cancer Therapy
@en
P2093
Larry M Karnitz
P2860
P304
P356
10.1158/1078-0432.CCR-15-0479
P407
P577
2015-09-11T00:00:00Z