The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis. - sprookjes - yvandenbroek - TriplyDB

The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis.

The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis.

http://www.wikidata.org/entity/Q39680127

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Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway mTOR Regulation of Lymphoid Cells in Immunity to Pathogens Molecular Mechanisms of White Spot Syndrome Virus Infection and Perspectives on Treatments Epilepsy related to developmental tumors and malformations of cortical development An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway Dysregulation of Autophagy Contributes to Anal Carcinogenesis The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC.Papillomavirus E6 oncoproteins.A phase 1 study of everolimus plus docetaxel plus cisplatin as induction chemotherapy for patients with locally and/or regionally advanced head and neck cancer.Inhibition of MMP-9 expression by ritonavir or saquinavir is associated with inactivation of the AKT/Fra-1 pathway in cervical intraepithelial neoplasia cells.Blockade of Axl signaling ameliorates HPV16E6-mediated tumorigenecity of cervical cancer.Reduced expression of autophagy markers correlates with high-risk human papillomavirus infection in human cervical squamous cell carcinoma Herpes Simplex Virus is Akt-ing in translational control.The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species DNA damage repair genes controlling human papillomavirus (HPV) episome levels under conditions of stability and extreme instability RSK activation of translation factor eIF4B drives abnormal increases of laminin γ2 and MYC protein during neoplastic progression to squamous cell carcinoma.Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.Role of Cdk1 in the p53-independent abrogation of the postmitotic checkpoint by human papillomavirus E6 E6 and E7 from human papillomavirus type 16 cooperate to target the PDZ protein Na/H exchange regulatory factor 1.Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation.Human papillomavirus in anal squamous cell carcinoma: an angel rather than a devil?Dominant role of HPV16 E7 in anal carcinogenesis.Poly(ADP-ribose) polymerase-13 and RNA regulation in immunity and cancer.The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38.Sterile α Motif Domain Containing 9 Is a Novel Cellular Interacting Partner to Low-Risk Type Human Papillomavirus E6 Proteins.MAPK/ERK-dependent translation factor hyperactivation and dysregulated laminin γ2 expression in oral dysplasia and squamous cell carcinoma.Cancer associated human papillomaviruses.Metformin impairs the growth of liver kinase B1-intact cervical cancer cells.mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas.Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy.HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures.Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition.Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses The mutational landscape of adenoid cystic carcinoma Biochemical and functional interactions of human papillomavirus proteins with polycomb group proteins.DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase Is focal cortical dysplasia an infectious disease?mTOR downstream effectors, 4EBP1 and eIF4E, are overexpressed and associated with HPV status in precancerous lesions and carcinomas of the uterine cervix.Modulation of autophagy-like processes by tumor viruses.

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The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis.

http://www.wikidata.org/entity/Q39680127

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2010 nî lūn-bûn

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name

The human papillomavirus type ...... d increases protein synthesis.

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The human papillomavirus type ...... d increases protein synthesis.

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The human papillomavirus type ...... d increases protein synthesis.

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The human papillomavirus type ...... d increases protein synthesis.

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The human papillomavirus type ...... d increases protein synthesis.

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Jennifer M Spangle

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Karl Münger

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P2860

Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins

Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase

The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation

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9398-9407

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10.1128/JVI.00974-10

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18

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