Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.
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Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7Synaptic function of nicastrin in hippocampal neuronsγ-Secretase inhibitors and modulators.Γ-secretase components as predictors of breast cancer outcomeModeling an anti-amyloid combination therapy for Alzheimer's disease.KSHV-induced notch components render endothelial and mural cell characteristics and cell survival.The secretases: enzymes with therapeutic potential in Alzheimer disease.Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.Central role of the EGF receptor in neurometabolic aging.Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged micePresenilins and γ-secretase: structure, function, and role in Alzheimer Disease.New pathway links γ-secretase to inflammation and memory while sparing notch.Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms.Identification and characterization of five intramembrane metalloproteases in Anabaena variabilis.Role for Notch signaling in salivary acinar cell growth and differentiationNotch tumor suppressor functionγ-Secretase inhibition promotes fibrotic effects of albumin in proximal tubular epithelial cells.Neurogenesis and Alzheimer's disease: at the crossroads.Amyloid precursor protein processing and Alzheimer's diseaseNotch signalling in solid tumours: a little bit of everything but not all the time.Can animal skin diseases or current transgenic mice serve as a model for hidradenitis suppurativa?Crossing paths in Human Renal Cell Carcinoma (hRCC).Targeted next-generation sequencing identifies molecular subgroups in squamous cell carcinoma of the head and neck with distinct outcome after concurrent chemoradiation.Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3-kinase/AKT signalling pathways.A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors.A Systematic Review and Critical Evaluation of Reported Pathogenic Sequence Variants in Hidradenitis Suppurativa.Γ-secretase modulators do not induce Aβ-rebound and accumulation of β-C-terminal fragment.Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage.Arsenite suppresses Notch1 signaling in human keratinocytes[Hidradenitis suppurativa/acne inversa: An update].Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma.Genetics. Gamma-secretase and human disease.EGFR signaling pathway and related-miRNAs in age-related diseases: the example of miR-221 and miR-222.American Association for Cancer Research Genetics and Biology of Brain Cancers 2009, December 13-15, 2009, San Diego, CA.[Acne inversa (hidradenitis suppurativa). From diagnosis to therapy].Hidradenitis suppurativa: haploinsufficiency of gamma-secretase components does not affect gamma-secretase enzyme activity in vitro.γ-Secretase gene mutations link acne inversa with Alzheimer's disease.
P2860
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P2860
Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Epidermal growth factor recept ...... r function of gamma-secretase.
@en
type
label
Epidermal growth factor recept ...... r function of gamma-secretase.
@en
prefLabel
Epidermal growth factor recept ...... r function of gamma-secretase.
@en
P2093
P2860
P356
P1476
Epidermal growth factor recept ...... r function of gamma-secretase.
@en
P2093
Abdul Fauq
Barbara J Crain
Cory Brayton
Donald L Price
Hongjin Wen
Lisa A Smithson
Philip C Wong
Pritam Das
Todd E Golde
P2860
P304
32264-32273
P356
10.1074/JBC.M703649200
P407
P577
2007-09-07T00:00:00Z