The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
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Usage of adenovirus expressing thymidine kinase mediated hepatocellular damage for enabling mouse liver repopulation with allogenic or xenogenic hepatocytesMalaria modeling: In vitro stem cells vs in vivo modelsFialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testingGeneration of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID MiceUsing chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction.Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound.Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice.Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections.Current advances in humanized mouse models.In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism.Higher Serum Alanine Transaminase Levels in Male Urokinase-Type Plasminogen Activator-Transgenic Mice Are Associated With Improved Engraftment of Hepatocytes but not Liver Sinusoidal Endothelial Cells.Novel enhanced green fluorescent protein-expressing NOG mouse for analyzing the microenvironment of xenograft tissuesMouse liver repopulation with hepatocytes generated from human fibroblasts.Visualizing hepatitis C virus infection in humanized mice.Can 'humanized' mice improve drug development in the 21st century?Generation of recombination activating gene-1-deficient neonatal piglets: a model of T and B cell deficient severe combined immune deficiency.Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicityHepatocytes buried in the cirrhotic livers of patients with biliary atresia proliferate and function in the livers of urokinase-type plasminogen activator-NOG mice.A versatile technique for the in vivo imaging of human tumor xenografts using near-infrared fluorochrome-conjugated macromolecule probes.Human induced hepatic lineage-oriented stem cells: autonomous specification of human iPS cells toward hepatocyte-like cells without any exogenous differentiation factors.Humanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: a case study with furosemide.The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice.Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice.Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized LiversHuman Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG MiceMetabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice.The nude mouse as model for liver deficiency study and treatment and xenotransplantation.In vivo models of hepatitis B and C virus infection.The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice.Chimeric mice with humanized livers: a unique tool for in vivo and in vitro enzyme induction studiesBaseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment.Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry.Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology.Liver immune-pathogenesis and therapy of human liver tropic virus infection in humanized mouse models.Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers.Cell fate conversion: direct induction of hepatocyte-like cells from fibroblasts.Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies.Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver.
P2860
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P2860
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
@en
type
label
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
@en
prefLabel
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
@en
P2093
P2860
P1476
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional
@en
P2093
Gary Peltz
Kenji Kawai
Kenji Taniguchi
Makoto Monnai
Makoto Suematsu
Mamoru Ito
Masami Hasegawa
Masato Nakamura
Masatoshi Wakui
Tetsuya Mitsui
P2860
P304
P356
10.1016/J.BBRC.2011.01.042
P577
2011-01-14T00:00:00Z