A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control. - sprookjes - yvandenbroek - TriplyDB

A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control.

A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control.

http://www.wikidata.org/entity/Q41922145

about

Novel Allosteric Modulators of G Protein-coupled Receptors Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation.Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity An allosteric antibody to the leptin receptor reduces body weight and reverses the diabetic phenotype in the Lep(ob) /Lep(ob) mouse.Glycemic control and chronic dosing of rhesus monkeys with a fusion protein of iduronidase and a monoclonal antibody against the human insulin receptor.Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling.Building the Case for Insulin-Like Growth Factor Receptor-I Involvement in Thyroid-Associated Ophthalmopathy.Selective allosteric antibodies to the insulin receptor for the treatment of hyperglycemic and hypoglycemic disorders.Novel therapeutic approaches for haemophilia.Can insulin signaling pathways be targeted to transport Aβ out of the brain?Pursuit of a perfect insulin.Differential Effects of Camel Milk on Insulin Receptor Signaling - Toward Understanding the Insulin-Like Properties of Camel Milk A Novel Allosteric Insulin Receptor-Activating Antibody Reduces Hyperglycemia without Hypoglycemia in Diabetic Cynomolgus Monkeys.Acute Treatment With XMetA Activates Hepatic Insulin Receptors and Lowers Blood Glucose in Normal Mice.A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia.Selective insulin receptor modulators (SIRM): a new class of antidiabetes drugs?A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model.Insulin Receptor Isoforms in Physiology and Disease: An Updated View.Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody.XMetA, an allosteric monoclonal antibody to the insulin receptor, improves glycaemic control in mice with diet-induced obesity.Allosteric modulation as a unifying mechanism for receptor function and regulation.Monoclonal Antibodies against the MET/HGF Receptor and Its Ligand: Multitask Tools with Applications from Basic Research to Therapy.

P2860

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P2860

A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control.

http://www.wikidata.org/entity/Q41922145

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

A fully human, allosteric mono ...... and improves glycemic control.

@en

type

label

A fully human, allosteric mono ...... and improves glycemic control.

@en

prefLabel

A fully human, allosteric mono ...... and improves glycemic control.

@en

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P1476

A fully human, allosteric mono ...... and improves glycemic control.

@en

P2093

Ajay J Narasimha

http://www.w3.org/2001/XMLSchema#string

Angela Lau

http://www.w3.org/2001/XMLSchema#string

Betty A Maddux

http://www.w3.org/2001/XMLSchema#string

Catarina Tran

http://www.w3.org/2001/XMLSchema#string

David Chemla-Vogel

http://www.w3.org/2001/XMLSchema#string

Diane Wilcock

http://www.w3.org/2001/XMLSchema#string

Hua F Kuan

http://www.w3.org/2001/XMLSchema#string

Ira D Goldfine

http://www.w3.org/2001/XMLSchema#string

John A Corbin

http://www.w3.org/2001/XMLSchema#string

Lisa M Gross

http://www.w3.org/2001/XMLSchema#string

P2860

Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography

Banting lecture 1988. Role of insulin resistance in human disease

Critical nodes in signalling pathways: insights into insulin action

Animal models of diabetes mellitus.

Relationship between plasma glucose and insulin concentration, glucose production, and glucose disposal in normal subjects and patients with non-insulin-dependent diabetes.

Pharmacological characterization of six trkB antibodies reveals a novel class of functional agents for the study of the BDNF receptor

The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.

The insulin receptor: a prototype for dimeric, allosteric membrane receptors?

Molecular mechanisms of insulin resistance in type 2 diabetes mellitus

P304

1263-1271

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scholarly article

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10.2337/DB11-1578

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P407

P433

5

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61

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Daniel H Bedinger

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2012-03-08T00:00:00Z

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221689178

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22403294

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3331746

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