Two levels of protection for the B cell genome during somatic hypermutation.
about
AID/APOBEC cytosine deaminase induces genome-wide kataegisOptimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutationSolubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminaseDNA demethylation dynamicsMicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocationMutations, kataegis and translocations in B cells: understanding AID promiscuous activityThe Link between Plasmodium falciparum Malaria and Endemic Burkitt's Lymphoma-New Insight into a 50-Year-Old EnigmaMolecular Pathogenesis of MALT LymphomaMolecular programming of B cell memoryRegulation of Aicda expression and AID activityThe genetic landscape of diffuse large B-cell lymphomaRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationIgH chain class switch recombination: mechanism and regulationMSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sitesAID targeting is dependent on RNA polymerase II pausing.AID/APOBEC deaminases and cancerRNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeConvergent transcription at intragenic super-enhancers targets AID-initiated genomic instabilityThe response to and repair of RAG-mediated DNA double-strand breaksIsotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutationAID targeting: old mysteries and new challengesAPOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA ReplicationAltered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC proteinmiR-181b negatively regulates activation-induced cytidine deaminase in B cellsThe splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNASimultaneous in vitro characterisation of DNA deaminase function and associated DNA repair pathwaysProcessive DNA demethylation via DNA deaminase-induced lesion resolutionAID and Apobec3G haphazard deamination and mutational diversityEffects of prostaglandin E2 on p53 mRNA transcription and p53 mutagenesis during T-cell-independent human B-cell clonal expansionIntegrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in miceHaploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo.A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.Mechanisms of chromosomal rearrangement in the human genomeAID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.AID-induced remodeling of immunoglobulin genes and B cell fate.AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.Role of the translocation partner in protection against AID-dependent chromosomal translocationsA coming-of-age story: activation-induced cytidine deaminase turns 10.The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.
P2860
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P2860
Two levels of protection for the B cell genome during somatic hypermutation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Two levels of protection for the B cell genome during somatic hypermutation.
@en
Two levels of protection for the B cell genome during somatic hypermutation.
@nl
type
label
Two levels of protection for the B cell genome during somatic hypermutation.
@en
Two levels of protection for the B cell genome during somatic hypermutation.
@nl
prefLabel
Two levels of protection for the B cell genome during somatic hypermutation.
@en
Two levels of protection for the B cell genome during somatic hypermutation.
@nl
P2093
P50
P356
P1433
P1476
Two levels of protection for the B cell genome during somatic hypermutation
@en
P2093
Daniel J Richter
David G Schatz
Steven H Kleinstein
P2888
P304
P356
10.1038/NATURE06547
P407
P577
2008-02-01T00:00:00Z
P6179
1026421044