The 1889 Purdue football team was an American football team that represented Purdue University during the 1889 college football season. The team compiled a 2–1 record in the university's second season fielding an intercollegiate football team. Archaeologist and Harvard alumnus, George Andrew Reisner, was the team's coach. The team opened its season on November 16, 1889, with a 34–10 victory over DePauw for the first victory in Purdue football history and the first game played in West Lafayette, Indiana. Purdue defeated Wabash the following week, 18–4, and concluded its season on November 29, 1889, with a 14–0 defeat to Butler.