The 1910 Purdue Boilermakers football team was an American football team that represented Purdue University during the 1910 college football season. In their first season under head coach Bill Horr, the Boilermakers compiled a 1–5 record, finished in last place in the Big Nine Conference with an 0–4 record against conference opponents, and were outscored by their opponents by a combined total of 65 to 19.