The XV edition of the Caribbean Series (Serie del Caribe) was played in 1972. It was held from February 1 through February 6 with the champions teams from Dominican Republic (Aguilas Cibaeñas), Mexico (Algodoneros de Guasave), Puerto Rico (Leones de Ponce) and Venezuela (Tigres de Aragua). The format consisted of 12 games, each team facing the other teams twice. The games were played at Estadio Quisqueya in Santo Domingo, D.R., which boosted capacity to 14.000 seats, and the first pitch was thrown by Joaquín Balaguer, by then the President of Dominican Republic.