The XXIII edition of the Caribbean Series (Serie del Caribe) was played in 1980. It was held from February 2 through February 7 with the champions teams from Dominican Republic (Tigres del Licey), Mexico (Naranjeros de Hermosillo), Puerto Rico (Vaqueros de Bayamón) and Venezuela (Leones del Caracas). The format consisted of 12 games, each team facing the other teams twice. The games were played at Estadio Quisqueya in Santo Domingo, D.R., which boosted capacity to 14.000 seats, and the first pitch was thrown by Antonio Guzmán, by then the President of Dominican Republic.