The 2006 Michigan State Spartans football team represented Michigan State University in the 2006 NCAA Division I FBS football season. Michigan State competed as a member of the Big Ten Conference, and played their home games at Spartan Stadium in East Lansing, Michigan. The Spartans were led by fourth-year head coach John L. Smith. Smith had compiled a combined 18–18 record in his previous seasons at Michigan State, and he was fired after the 2006 season in which the team finished 4–8. The Spartans did, however, set the record for the greatest comeback from a deficit in college football history.