The 2006 Millsaps Majors football team represented Millsaps College during the 2006 college football season. Coach DuBose's first season got off to a rocky start. The Majors were hammered 52-28 by Mississippi College in the season-opening Backyard Brawl game, which returned after a one-year hiatus in 2005. The Majors then lost their next two games in heartbreaking fashion, by a combined total of four points. However, DuBose's team managed an incredible turn-around that shocked the SCAC, when the team went on to win their next six games to set up a showdown with perennial SCAC juggernaut Trinity in the season finale. Each team entered the contest at 5-0 in conference play, meaning the winner would receive the SCAC's automatic playoff bid and claim the SCAC title outright.