The 2010 William & Mary Tribe football team represented The College of William & Mary in the 2010 NCAA Division I FCS football season. William & Mary competed as a member of the Colonial Athletic Association (CAA) under head football coach Jimmye Laycock and played their home games at Zable Stadium. The Tribe clinched a share of the CAA championship in the final week of the regular season. Entering Week 11, they had to defeat #18 Richmond and have #15 Villanova upset #1 Delaware, and both of those results happened. The Tribe reclaimed the Capital Cup by defeating the Spiders, 41–3, and Villanova surprised Delaware, 28–21, in overtime. William & Mary and Delaware shared the title.