"6th Avenue Heartache" is a song by American rock band The Wallflowers. It was released in April 1996 as the lead single from their 1996 debut album Bringing Down the Horse. The song became their first hit, peaking at number 8 on the US Modern Rock Tracks chart, number 10 on the US Mainstream Rock Tracks chart, and number 33 on the US Hot 100 Airplay chart. Though the song was a hit on rock radio, it was overshadowed by its follow-up single, "One Headlight." The background vocals in this song are by Adam Duritz from Counting Crows.