AL-34662
AL-34662 is an indazole derivative drug that is being developed for the treatment of glaucoma. It acts as a selective 5-HT2A receptor agonist, the same target as that of psychedelic drugs like psilocin, but unlike these drugs, AL-34662 was designed specifically as a peripherally selective drug, which does not cross the blood–brain barrier. This means that AL-34662 can exploit a useful side effect of the hallucinogenic 5-HT2A agonists, namely reduction in intra-ocular pressure and hence relief from the symptoms of glaucoma, but without causing the hallucinogenic effects that make centrally active 5-HT2A agonists unsuitable for clinical use. In animal studies, AL-34662 has been shown to be potent and effective in the treatment of symptoms of glaucoma, with minimal side effects.
primaryTopic
AL-34662
AL-34662 is an indazole derivative drug that is being developed for the treatment of glaucoma. It acts as a selective 5-HT2A receptor agonist, the same target as that of psychedelic drugs like psilocin, but unlike these drugs, AL-34662 was designed specifically as a peripherally selective drug, which does not cross the blood–brain barrier. This means that AL-34662 can exploit a useful side effect of the hallucinogenic 5-HT2A agonists, namely reduction in intra-ocular pressure and hence relief from the symptoms of glaucoma, but without causing the hallucinogenic effects that make centrally active 5-HT2A agonists unsuitable for clinical use. In animal studies, AL-34662 has been shown to be potent and effective in the treatment of symptoms of glaucoma, with minimal side effects.
has abstract
AL-34662 is an indazole deriva ...... priate responding in animals.
@en
CAS number
210580-75-9
IUPAC name
1-((S)-2-Aminopropyl)-1H-indazol-6-ol
@en
thumbnail
Wikipage page ID
20,021,302
Wikipage revision ID
713,191,489
ChEMBL
ChemSpiderID
21,467,821
melting high
melting point
molecular weight
1.91229e+2
smiles
CCCn1ncc2ccccc12
StdInChIKey
WBYHTZYHAFNBKW-ZETCQYMHSA-N
Verifiedfields
verifiedrevid
477,235,652
hypernym
comment
AL-34662 is an indazole deriva ...... ma, with minimal side effects.
@en
label
AL-34662
@en