A 44-Calibre Mystery is a 1917 American short Western film, featuring Harry Carey. Carey plays the role of Sheriff Cheyenne Harry. He saves Kitty Flanders from Pete McGuire and takes her safely home. McGuire hides in a shack on Mr. Flanders' stake and Harry's deputy is shot dead, apparently by Mr. Flanders. McGuire offers to keep quiet about the murder if Flanders gives him half a stake and his daughter's hand in marriage. Mr. Flanders confesses his crime to Sheriff Harry and learns that he is innocent. Sheriff Harry notices McGuire's gun and accuses him of the crime, but they are killed as they try to escape. The film concludes as Kitty Flanders confesses her love to Sheriff Cheyenne as she bandages his wounds from the fight.