The Agawam Center Historic District is a historic district that encompasses part of the historic center of Agawam, Massachusetts. The district covers most of the buildings along Elm Street and Main Street radiating out from their intersection in both directions. The district is predominantly residential in character, although it does contain a number of commercial, industrial, and civic buildings. Many of the buildings in the district stand at a uniform setback from the street, giving the district a coherent feel.