Alinidine
Alinidine (ST567) is a negative chronotrope that was developed in the 1970s and 1980s. It causes bradycardia by inhibiting the pacemaker current by altering the maximal channel conductance and alter the voltage threshold. The development of alinidine was halted because it was not sufficiently specific for its target. It also has a blocking effect on calcium channels and potassium channels. It also causes elongation of re-polarisation after an action potential. Alinidine did not improve outcomes among patients with acute myocardial infarction in a randomized controlled trial.
primaryTopic
Alinidine
Alinidine (ST567) is a negative chronotrope that was developed in the 1970s and 1980s. It causes bradycardia by inhibiting the pacemaker current by altering the maximal channel conductance and alter the voltage threshold. The development of alinidine was halted because it was not sufficiently specific for its target. It also has a blocking effect on calcium channels and potassium channels. It also causes elongation of re-polarisation after an action potential. Alinidine did not improve outcomes among patients with acute myocardial infarction in a randomized controlled trial.
has abstract
Alinidine (ST567) is a negativ ...... a randomized controlled trial.
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ATC prefix
CAS number
33178-86-8
FDA UNII code
E7IDJ8DS1D
IUPAC name
N-(2,6-dichlorophenyl)-N-(prop-2-en-1-yl)-4,5-dihydro-1H-imidazol-2-amine
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PubChem
thumbnail
Wikipage page ID
26,138,283
Wikipage revision ID
721,604,585
ChEMBL
ChemSpiderID
legal status
molecular weight
smiles
Clc2ccccc2NC\C=C
StdInChIKey
OXTYVEUAQHPPMV-UHFFFAOYSA-N
Verifiedfields
verifiedrevid
477,317,415
hypernym
comment
Alinidine (ST567) is a negativ ...... a randomized controlled trial.
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label
Alinidine
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