Amoeba Cleansing Syndrome is the second studio album from American R&B singer Joi. The album was set to be released in 1996, under EMI Records and promotional CD's was released to radio stations. EMI soon delayed Amoeba Cleansing Syndrome set for a later release in 1997, for more songs with commercial appeal. By 1997, the album was planned for release, as "Ghetto Superstar" was to be first single. Abruptly, EMI Records was shut down, and the album was shelved. In The New Rolling Stone Album Guide (2004), Rolling Stone journalist Jon Caramanica calls the album both "sensational" and "bizzare".