The term Antidicomarianites (Greek ἀντιδικοµαριανῖται, literally "opponents of Mary", from ἀντίδικ-ος adversary + Μαρία Mary) was a term used by defenders of the doctrine of the perpetual virginity of Mary during the 4th and 5th centuries. It was pejoratively applied to Christians who believed that the brothers and sisters of Jesus mentioned in the New Testament were not children of Joseph by an earlier marriage — as had become orthodoxy by the 3rd century — but the younger children of Joseph and Mary after the birth of Jesus. There is no evidence that these Christians considered themselves to be "against Mary" in any sense, except of her being the "Queen of Heaven", which Roman Catholics and Orthodox Christians used as a title for her, a reflection of the biblical image in Revelation 12.