Autoimmune lymphoproliferative syndrome
Autoimmune lymphoproliferative syndrome (ALPS), also known as Canale-Smith syndrome, is a form of lymphoproliferative disorder (LPDs). It affects lymphocyte apoptosis. It is a RASopathy. It is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Normally, after infectious insult, the immune system down-regulates by increasing Fas expression on activated B and T lymphocytes and Fas-ligand on activated T lymphocytes. Fas and Fas-ligand interact to trigger the caspase cascade, leading to cell apoptosis. Patients with ALPS have a defect in this apoptotic pathway, leading to chronic non-malignant lymphoproliferation, autoimmune disease, and secondary cancers.
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Autoimmune lymphoproliferative syndrome
Autoimmune lymphoproliferative syndrome (ALPS), also known as Canale-Smith syndrome, is a form of lymphoproliferative disorder (LPDs). It affects lymphocyte apoptosis. It is a RASopathy. It is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Normally, after infectious insult, the immune system down-regulates by increasing Fas expression on activated B and T lymphocytes and Fas-ligand on activated T lymphocytes. Fas and Fas-ligand interact to trigger the caspase cascade, leading to cell apoptosis. Patients with ALPS have a defect in this apoptotic pathway, leading to chronic non-malignant lymphoproliferation, autoimmune disease, and secondary cancers.
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25بك المحتوى هنا ينقصه الاستشه ...... زية: Lymphoma).
* 32xبوابة طب
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Auto-immuun lymfoproliferatief ...... poptotische eiwit BIM een rol.
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Autoimmune lymphoproliferative ...... isease, and secondary cancers.
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Décrit en 1967, le syndrome ly ...... olifératifs de cause inconnue.
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El síndrome linfoproliferativo ...... o del grupo de las rasopatías.
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739,798,628
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25بك المحتوى هنا ينقصه الاستشه ...... راض التي تقع تحت هذه المجموعة:
@ar
Auto-immuun lymfoproliferatief ...... PS behoort tot de weesziekten.
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Autoimmune lymphoproliferative ...... isease, and secondary cancers.
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Décrit en 1967, le syndrome ly ...... lifératif avec auto-immunité :
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El síndrome linfoproliferativo ...... o del grupo de las rasopatías.
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Auto-immuun lymfoproliferatief syndroom
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Autoimmune lymphoproliferative syndrome
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Syndrome lymphoprolifératif avec auto-immunité
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Síndrome linfoproliferativo autoinmune
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مرض التكاثر الليمفاوي
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Autoimmune lymphoproliferative syndrome
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