Bloomsbury is an area in the West End, central London, forming part of the London Borough of Camden and located between Euston Road and Holborn. It was developed by the Russell family in the 17th and 18th centuries into a fashionable residential area. It is notable for its array of garden squares, literary connections (exemplified by the Bloomsbury Group), and numerous cultural, educational and health-care institutions. Although Bloomsbury was not the first area of London to have acquired a formal square, Bloomsbury Square, laid out in 1660 by Thomas Wriothesley, 4th Earl of Southampton, as Southampton Square was the first square to be named as such. Much of the district was planned and built by James Burton.