Broadway-Middle Historic District is a national historic district located at Cape Girardeau, Cape Girardeau County, Missouri. The district encompasses 24 contributing buildings in the central business district of Cape Girardeau. It developed between about 1868 and 1957, and includes representative examples of Greek Revival, Italianate, and Mission Revival style architecture. Notable buildings include Walther's Furniture and Undertaking (1916), I. Ben Miller Store (c. 1915), Lueders Studio (c. 1925), Graessle Building (c. 1908), Charles Rueseler Building (c. 1880), and A.C. Vasterling Building (c. 1903).