Caldwell-Hampton-Boylston House is a historic home located at Columbia, South Carolina. It was built between 1820 and 1830, and is a three-story, five bay, clapboard clad frame dwelling in the Greek Revival style. It features a two-story, projecting front porch. Also on the property is contributing ironwork and brick fencing (c. 1855), and a stable/carriage house, garden gazebo, and tea house. In 1874–1876, it was the residence of South Carolina Reconstruction governor Daniel H. Chamberlain, who purchased the house in 1869.