The Cancer Research Institute (CRI) is a US non-profit organization funding cancer research and based in New York City. They were founded in 1953 to develop immunologically-based treatments for cancer, and despite their name are a funding body for research rather than a research institute themselves, working with other institutes and organizations. It was founded by Helen Coley Nauts and Oliver R. Grace with a $2,000 grant from Nelson Rockefeller. CRI was created in honor of Nauts' father, William Coley (1862–1936), an American orthopedic surgeon and a pioneer of cancer immunotherapy. Like Dr. Coley, the Institute focuses on immunological treatments for cancer, rather than traditional treatments, such as chemotherapy and surgery.