Chou's distorted key theory for peptide drugs
As a culprit of AIDS, HIV protease has been a target for developing drugs against AIDS. Functioning as a dimer of two identical subunits, HIV protease has a crab-like shape (Fig.1). Its catalytic cleft is gated by a pair of flaps (or pincers if viewed as a crab). When the enzyme is in an inhibitor-free state, the pincer-gate is open, allowing substrates to enter the catalytic cleft (Fig.1); when in an inhibitor-binding state, the pincer-gate is closed, blocking the entrance.
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Chou's distorted key theory for peptide drugs
As a culprit of AIDS, HIV protease has been a target for developing drugs against AIDS. Functioning as a dimer of two identical subunits, HIV protease has a crab-like shape (Fig.1). Its catalytic cleft is gated by a pair of flaps (or pincers if viewed as a crab). When the enzyme is in an inhibitor-free state, the pincer-gate is open, allowing substrates to enter the catalytic cleft (Fig.1); when in an inhibitor-binding state, the pincer-gate is closed, blocking the entrance.
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As a culprit of AIDS, HIV prot ...... n octapeptide region (Fig.2) .
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40.066.220
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720.637.972
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As a culprit of AIDS, HIV prot ...... closed, blocking the entrance.
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Chou's distorted key theory for peptide drugs
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