Cortical dysplasia

Focal cortical dysplasia (FCD) is a congenital abnormality of brain development where the neurons in an area of the brain failed to migrate in the proper formation in utero. Focal cortical dysplasia is a common cause of intractable epilepsy in children and is a frequent cause of epilepsy in adults. There are several subtypes of FCD including type 1a, 1b, 2a, 2b, 3a, 3b, and 3c, each with distinct histopathological features. All forms of focal cortical dysplasia lead to disorganization of the normal structure of the cerebral cortex. Type 1 FCD exhibits subtle alterations in cortical lamination. Type 2a FCD exhibits neurons that are larger than normal that are called cytomegalic dysmorphic neurons (CDN). FCD type 2b exhibits complete loss of laminar structure, and the presence of CDN and enl

Cortical dysplasia

Focal cortical dysplasia (FCD) is a congenital abnormality of brain development where the neurons in an area of the brain failed to migrate in the proper formation in utero. Focal cortical dysplasia is a common cause of intractable epilepsy in children and is a frequent cause of epilepsy in adults. There are several subtypes of FCD including type 1a, 1b, 2a, 2b, 3a, 3b, and 3c, each with distinct histopathological features. All forms of focal cortical dysplasia lead to disorganization of the normal structure of the cerebral cortex. Type 1 FCD exhibits subtle alterations in cortical lamination. Type 2a FCD exhibits neurons that are larger than normal that are called cytomegalic dysmorphic neurons (CDN). FCD type 2b exhibits complete loss of laminar structure, and the presence of CDN and enl