The Crewe to Manchester Line is a railway line in north west England, running from Crewe north east to Manchester. The line was built by the Manchester and Birmingham Railway Company, which diverted to Crewe in 1841 and merged in 1846 with others to form the London and North Western Railway Company, which in turn became part of the London Midland and Scottish Railway in 1923. In April 2006, Network Rail organised its maintenance and train control operations into "26 Routes" and the Crewe to Manchester line was included in Route 20 (North West Urban).