Dermatophyllum gypsophilum is a rare species of flowering plant in the legume family known by the common names Guadalupe Mountain necklacepod, Guadalupe mescalbean (var. guadalupensis), and gypsum necklace. It is native to New Mexico and Texas in the United States, and it is known from one location in Chihuahua in Mexico. This shrub grows up to 2 meters in height and has leathery, silver-haired leaves and purple flowers.