The Dr. John R. Drish House, also known simply as the Drish House, is a historic plantation house in Tuscaloosa, Alabama, United States. It is considered by state preservationists to be one of the most distinctive mixes of the Greek Revival and Italianate styles in Alabama. First recorded by the Historic American Buildings Survey in 1934, it was added to the Alabama Register of Landmarks and Heritage on July 31, 1975, and subsequently to the state's "Places in Peril" listing in 2006. It was listed on the National Register of Historic Places in 2015.