The E.S. Swayze Drugstore in Otisville, Michigan is a building from 1874. It was constructed to replace a previous store that burned in 1874. The second floor meeting hall was used by the Free Methodist Church for services from 1887 to 1890. In 1903 Otisville Lodge #401 (a local Masonic lodge) purchased the building, and used it as their meeting hall. It was owned by the Masons until 1970. The lodge has moved to other premises. It was listed on the National Register of Historic Places in 1982 and designated as a Michigan State Historic Site in 2010.