Elsmere is a hamlet of the town of the Bethlehem in Albany County, New York. The hamlet is a suburb of the neighboring city of Albany. From the northeast to the southwest it is bisected by New York Route 443 (Delaware Avenue) which is also the main street and a major commuter route into Albany. Delaware Ave is also home to most of the office and retail locations in Elsmere, including the largest- Delaware Plaza. Residential buildings tend to be on side streets north and south of Delaware Ave.