Etoperidone
Etoperidone (Axiomin, Centren, Depracer, Etonin, Etoran, Staff, Tropene), also known as clopradone and triazolinone, is an antidepressant of the phenylpiperazine class which was introduced in Europe in 1977. It acts primarily as an antagonist of several receptors in the following order of potency: 5-HT2A receptor (36 nM) > α1-adrenergic receptor (38 nM) > 5-HT1A receptor (85 nM) > α2-adrenergic receptor (570 nM); it has only very weak or negligible affinity for blocking the following receptors: D2 receptor (2,300 nM) > H1 receptor (3,100 nM) > mACh receptors (>35,000 nM). In addition to its receptor blockade, etoperidone also has weak affinity for the monoamine transporters as well: serotonin transporter (890 nM) > norepinephrine transporter (20,000 nM) > dopamine transporter (52,000 nM).
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Etoperidone
Etoperidone (Axiomin, Centren, Depracer, Etonin, Etoran, Staff, Tropene), also known as clopradone and triazolinone, is an antidepressant of the phenylpiperazine class which was introduced in Europe in 1977. It acts primarily as an antagonist of several receptors in the following order of potency: 5-HT2A receptor (36 nM) > α1-adrenergic receptor (38 nM) > 5-HT1A receptor (85 nM) > α2-adrenergic receptor (570 nM); it has only very weak or negligible affinity for blocking the following receptors: D2 receptor (2,300 nM) > H1 receptor (3,100 nM) > mACh receptors (>35,000 nM). In addition to its receptor blockade, etoperidone also has weak affinity for the monoamine transporters as well: serotonin transporter (890 nM) > norepinephrine transporter (20,000 nM) > dopamine transporter (52,000 nM).
has abstract
Etoperidona é um antidepressiv ...... nM) > α2-adrenergic (570 nM);
@pt
Etoperidone (Axiomin, Centren, ...... amine transporter (52,000 nM).
@en
L'étopéridone est un agent ant ...... é introduit en Europe en 1977.
@fr
ATC prefix
ATC suffix
CAS number
52942-31-1
FDA UNII code
KAI6MVO39Z
IUPAC name
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]
@en
propyl]-4,5-diethyl-1,2,4-triazol-3-one
@en
PubChem
thumbnail
Wikipage page ID
Wikipage revision ID
722,780,157
ChEMBL
ChemSpiderID
legal status
molecular weight
3.77911e+2
routes of administration
smiles
StdInChIKey
IZBNNCFOBMGTQX-UHFFFAOYSA-N
synonyms
Verifiedfields
verifiedrevid
447,570,339
comment
Etoperidona é um antidepressiv ...... nM) > α2-adrenergic (570 nM);
@pt
Etoperidone (Axiomin, Centren, ...... amine transporter (52,000 nM).
@en
L'étopéridone est un agent ant ...... é introduit en Europe en 1977.
@fr
label
Etoperidona
@pt
Etoperidone
@en
Étopéridone
@fr