The Farmer's and Manufacturer's Bank building is located at the corner of Market and Cannon Streets in downtown Poughkeepsie, New York, United States, near the Bardavon and across from the Dutchess County Court House and Old Poughkeepsie YMCA. It is one of only two non-residential Greek Revival buildings remaining in the city. It would be a landmark of the city's downtown for much of the 19th century. The bank itself would later become Empire National Bank and relocate elsewhere. One of its original trustees and later president was Matthew Vassar, founder of the eponymous college.