The Greek Revival First Presbyterian Church of Marcellus is located at the intersection of North Street (New York State Route 174) and East Main Street (also NY 174) in the village of Marcellus, New York, and is the oldest of four churches in the village. Marcellus village was founded in 1794. Local residents with differing religious denominations met in a tavern, until October 1801 when Reverend Caleb Alexander, a missionary active in the central New York area, helped organize the 18-member Church of Christ. A wooden meeting house was constructed two years later.