The George Pickering Nichols House is an historic house at 42 Thompson Road in Thompson, Connecticut. It is a 2-1/2 story wood frame structure, three bays wide, with a front gable roof and a single-story hip-roofed front porch extending across the front. A long two-story wing extends to the west (left) of the main block. The corners of the building are pilasters, supporting a frieze and entablature at the cornice. A polygonal bay, added c. 1880, projects from the east side of the main block, and is decorated with brackets. The house was built c. 1846 by George Pickering Nichols, who came from a family of early area settlers.