George Tilles, Sr. (September 11, 1859 – November 26, 1929) was an American businessman, philanthropist, and an early developer of the city of Fort Smith, Arkansas. Tilles was the older brother to Cap Tilles, a St. Louis capitalist and philanthropist. During his career, Tilles became a prolific entrepreneur and established a variety of businesses in manufacturing, insurance, brokerage, telephone communications, local theatrical production, and commercial property. He was also involved in charitable activities, most notably supportive of tuberculosis care, in memory of his younger brother Manny who died of the disease as a teenager.