State Route 22 (SR 22) is a 221.1-mile-long (355.8 km) state highway that runs southwest-to-northeast in an eastern arc through portions of Muscogee, Talbot, Taylor, Upson, Crawford, Bibb, Jones, Baldwin, Hancock, Taliaferro, Oglethorpe, and Madison counties in the western and west-central parts of the U.S. state of Georgia. The route connects the Alabama state line in Columbus, across the state line from Phenix City, Alabama, to Comer, via Macon and Milledgeville.