The Goodwin-Harrison House is a historic mansion in Macon, Mississippi, U.S.. It was built in 1852 for W. W. Goodwin, a planter. It was designed in the Greek Revival architectural style. From 1873 to 1882, it was home to a boys' school run by W. W. Baird. It was purchased by Nathaniel H. Harrison, a banker, in 1882. It has been listed on the National Register of Historic Places since November 28, 1980.