The Great Plague of Seville (1647–1652) was a massive outbreak of disease in Spain that killed up to a quarter of Seville's population. Unlike the plague of 1596–1602, which claimed 600,000 to 700,000 lives, or a little under 8% of the population and initially struck northern and central Spain and Andalusia in the south, the Great Plague, which may have arisen in Algeria, struck the Mediterranean side of Spain first. The coastal city of Valencia was the first city to be hit, losing an estimated 30,000 people. The disease raged through Andalucía, in addition to sweeping the north into Catalonia and Aragon. The coast of Málaga lost upwards of 50,000 people. In Seville, quarantine measures were evaded, ignored, unproposed and/or unenforced. Unsurprisingly, the result was horrific. The city of