HMS Bristol was a 50-gun Portland-class fourth-rate ship of the line, built for the Royal Navy in the 1770s. She served as a flagship during the Battle of Sullivan's Island, Charleston, South Carolina in 1776 during the American Revolutionary War and later participated in the 1783 Battle of Cuddalore during the Anglo-French War of 1778–83. By 1787 the ship had been converted into a church ship. Converted into a prison ship in 1794, Bristol instead served as a hospital ship until she was broken up in 1810.