James S. Hyde (born 1932) is an American biophysicist. He holds the James S. Hyde chair in Biophysics at the Medical College of Wisconsin (MCW) where he specializes in magnetic resonance instrumentation and methodology development in two distinct areas: electron paramagnetic resonance (EPR) spectroscopy and magnetic resonance imaging (MRI). He is senior author of the widely cited 1995 paper by B.B. Biswal et al. reporting the discovery of resting state functional connectivity (fcMRI) in the human brain. He also serves as Director of the National Biomedical EPR Center, a Research Resource supported by the National Institutes of Health. He is author or more than 400 peer-reviewed papers and review articles and holds 35 U.S. Patents. He has been recognized by Festschrifts in both EPR and fcM