The Jesse R. Siler House is a historic house at 115 West Main Street in Franklin, North Carolina. It is prominently sited at the base of the hill on which most of the city is located. A two-story log structure was built on this site c. 1819, and expanded between 1820 and 1830 by Jesse Siler, a prominent early settler of the area. It was modified significantly over the 19th century, most notably receiving a prominent Greek Revival tetrastyle portico. It retains many interior features from Siler's period of modification, exhibiting transitional Georgian-Federal styling in its mantels.