The Lenoir Cotton Mill was a 19th-century cotton mill located in the U.S. city of Lenoir City, Tennessee. One of the earliest examples of industrial architecture in Tennessee, the mill operated variously from its construction around 1830 until the 1950s. The mill was documented by the Historic American Buildings Survey and placed on the National Register of Historic Places in the 1970s. Efforts to restore the mill began in 1980, but before the restoration could be completed, the mill was destroyed by arson in 1991.