The Lewis and Clark River Bridge is a bascule bridge that spans the Lewis and Clark River on U.S. Route 101 Business (a section originally part of U.S. Route 101) in Clatsop County, Oregon. It was designed by Conde McCullough and opened in 1925. It was built to replace an earlier bridge at the same location, a swing-span bridge constructed around 1910. The total length of the bridge is 828 feet (252 m), and the length of the bascule main span is 112 ft (34 m). The approach spans consist of a total of 48 timber pile and stringer spans.