Lofentanil
Lofentanil is one of the most potent opioid analgesics known and is an analogue of fentanyl, which was developed in 1960. It is most similar to the highly potent opioid carfentanil (4-carbomethoxyfentanyl), only slightly more potent. Lofentanil can be described as 3-methylcarfentanil, or 3-methyl-4-carbomethoxyfentanyl. While 3-methylfentanyl is considerably more potent than fentanyl itself, lofentanil is only slightly stronger than carfentanil. This suggests that substitution at both the 3 and 4 positions of the piperidine ring introduces steric hindrance which prevents μ-opioid affinity from increasing much further. As with other 3-substituted fentanyl derivatives such as ohmefentanyl, the stereoisomerism of lofentanil is very important, with some stereoisomers being much more potent tha
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Lofentanil
Lofentanil is one of the most potent opioid analgesics known and is an analogue of fentanyl, which was developed in 1960. It is most similar to the highly potent opioid carfentanil (4-carbomethoxyfentanyl), only slightly more potent. Lofentanil can be described as 3-methylcarfentanil, or 3-methyl-4-carbomethoxyfentanyl. While 3-methylfentanyl is considerably more potent than fentanyl itself, lofentanil is only slightly stronger than carfentanil. This suggests that substitution at both the 3 and 4 positions of the piperidine ring introduces steric hindrance which prevents μ-opioid affinity from increasing much further. As with other 3-substituted fentanyl derivatives such as ohmefentanyl, the stereoisomerism of lofentanil is very important, with some stereoisomers being much more potent tha
has abstract
Lofentanil is one of the most ...... ; EC50 = 153 nM; Emax = 100%).
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Lofentanil ist eine synthetisc ...... m 6000-fachen der von Morphin.
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Lofentanil è uno dei più poten ...... he sia particolarmente rapida.
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ATC prefix
CAS number
61380-40-3
FDA UNII code
7H7YQ564XV
IUPAC name
methyl (3S,4R)-3-methyl-1-(2-p ...... amino]piperidine-4-carboxylate
@en
PubChem
thumbnail
Wikipage page ID
12,790,638
Wikipage revision ID
744,312,069
ChEMBL
ChemSpiderID
legal DE
legal UK
molecular weight
4.08533e+2
smiles
O=C[C@]3CCNC[C@H]3C
StdInChIKey
IMYHGORQCPYVBZ-NLFFAJNJSA-N
synonyms
Lofentanil; (methyl -1--4 --3-methylpiperidine-4-carboxylate)
Verifiedfields
verifiedrevid
462,093,198
subject
hypernym
comment
Lofentanil is one of the most ...... ers being much more potent tha
@en
Lofentanil ist eine synthetisc ...... m 6000-fachen der von Morphin.
@de
Lofentanil è uno dei più poten ...... e inadatto per la maggior part
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label
Lofentanil
@de
Lofentanil
@en
Lofentanil
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