M-49 is a north–south state trunkline highway in the south-central portion of the US state of Michigan. It runs from the Ohio state line north to Litchfield through rural Hillsdale County. M-49 is the only Michigan highway in which the road crossing into another state has the same state highway number. M-49 continues as State Route 49 (SR 49), near the Indiana–Michigan–Ohio tripoint south of Camden. The highway dates back to 1930 and was only altered once in the 1940s. M-49 runs through Southern Michigan farmlands connecting several small towns along its path.