The Manistique and Lake Superior Railroad (M&LS) was an American Class III railroad serving the Upper Peninsula of Michigan from 1909 to 1968. It provided service from Manistique, Michigan to a junction with the Duluth, South Shore and Atlantic Railway at Doty, Michigan, southeast of Munising, Michigan. Its nickname was The Haywire. The M&LS connected with the Duluth, South Shore and Atlantic Railway in Shingleton, just east of Munising and with the Lake Superior and Ishpeming Railroad at Doty, as well as with the Soo Line in its headquarters of Manistique.