Medusandra is a genus of flowering plants in the family Peridiscaceae. It has two species, Medusandra richardsiana and Medusandra mpomiana. M. richardsiana is the most common and well known. Both species are native to Cameroon and adjacent countries. Medusandra was named by John Brenan in 1952. Brenan put Medusandra in its own family, Medusandraceae, and added Soyauxia to that family in 1953. Most authors, however, maintained Medusandraceae as a monogeneric family and put Soyauxia elsewhere. A detailed description of Medusandra was published by John Hutchinson in 1973.