The Monroe County Bank Building is a historic commercial building at 225-227 West Cypress Street in Brinkley, Arkansas. It is a two story brick building, with brick and stone trim elements. It houses three storefronts on the ground floor, with professional offices and other spaces on the upper floor. It was built about 1889, and its facade was redone in 1909 after suffering extensive damage caused by a tornado. The Monroe County Bank, for whom it was built, was the town's first major bank, and occupied the building until the 1930s. Its upper level also housed the town's largest performance venue of the time.